楼建林

资讯来源:新葡的京集团网址发布时间:2022-09-06点击量:10

基本信息:

楼建林,男,浙江大学劳动卫生与环境卫生学博士,美国哈佛大学访问学者,研究员,硕士研究生导师。

人才称号:

1. 浙江省新世纪151人才工程第二层次

2.浙江省高校创新领军人才

学术任职:

1.中国毒理学会灾害与应急毒理学专业委员会副主任委员

2.浙江省预防医学会劳动卫生与职业病专业委员会主任委员

3.中华预防医学会劳动卫生与职业病专业委员会常务委员

研究方向:

主要从事生物标志物筛选鉴定与功能研究、职业性呼吸系统疾病和职业性肿瘤的发病机制和早期诊断标志物研究

主持项目

1.神经嵴源细胞介导尘肺纤维化的分子机制研究,国家重点研发计划项目,2020年-2023 年;

2.循环神经嵴源细胞在矽肺纤维化病变中的作用及临床应用研究,浙江省部共建重点项目,2020 年-2022 年;

3.核糖体DNA 拷贝数变异在六价铬诱发DNA 损伤反应中的作用及机制研究,,国家自然科学基金面上项目,2019 年-2022 年;

4.六价铬职业接触人群血浆DNA 损伤反应相关microRNA 的鉴定及功能研究,国家自然科学基金面上项目,2015 年-2018 年;

5.职业健康监护技术研究实验室建设,浙江省科技厅,2015 年-2016 年;

6.恶性间皮瘤监测体系及诊断技术研究,浙江省科技厅重大专项,2014 年-2017年。

主要论文

1. Shi L, Feng L, Tong Y, Jia J, Li T, Wang J, Jiang Z, Yu M, Xia H, Jin Q, Jiang X, Cheng Y, Ju L, Liu J, Zhang Q, Lou J*. Genome wide profiling of miRNAs relevant to the DNA damage response induced by hexavalent chromium exposure (DDR-related miRNAs in response to Cr (VI) exposure). Environ Int. 2021 Dec;157:106782. doi: 10.1016/j.envint.2021.106782. Epub 2021 Jul 28.

2. Lou J, Yu S, Feng L, Guo X, Wang M, Branco AT, Li T, Lemos B. Environmentally induced ribosomal DNA (rDNA) instability in human cells and populations exposed to hexavalent chromium [Cr (VI)]. Environ Int. 2021 Aug;153:106525. doi: 10.1016/j.envint.2021.106525. Epub 2021 Mar 25.

3. Qi T, Huang Y, Li S, Ying Q, Jiang Z, Ma L, Li C, Chen P, Xu W, Lan Y, Chu K, Xu L, Lou J*., Yu W, Zhou J. Associations of age at natural menopause and occupations in Chinese female workers: A cross-sectional study. Environ Res. 2021 Jan 28;195:110776.

4. Jiang Z, Shen W, Ying S, Gao Z, He X, Chen R, Xia H, Guo X, Fang Y, Zhang Y, Miao J, Zhou J, Zhang X, Chen J, Lou J*. Overexpression of fibulin-3 in tumor tissue predicts poor survival of malignant mesothelioma patients from hand-spinning asbestos exposed area in eastern China. Sci Rep. 2020 Nov 23;10(1):20373

5. Hailing Xia, Lingfang Feng, Lijun Lin, ZhaoqiangJiang, Junqiang Chen, Wei Shi, Shibo Ying, Min Yu, Li Ju, Lijin Zhu, Li Shi, Xing Zhang, JianlinLou*. Exploration of identifying novel serum biomarkers for malignant mesothelioma using iTRAQ combined with 2DLC-MS/MS, Environmental Research, 2021 February;193:110467. doi: 10.1016/j.envres.2020.110467.

6. Lingfang Feng, Jing Du, Chunji Yao, Zhaoqiang Jiang, Tao Li, Quan Zhang, Xinnian Guo, Min Yu, Hailing Xia, Li Shi, Junlin Jia, Yan Tong, Li Ju, Jiaqi Liu, Jianlin Lou*, Bernardo Lemos. Ribosomal DNA copy number is associated with P53 status and levels of heavy metals in gastrectomy specimens from gastric cancer patientsEnviron Int. 2020 May;138:105593. doi: 10.1016/j.envint.2020.105593.

7. Lingfang Feng, Xinnian Guo, Tao Li, Chunji Yao, Hailing Xia, Zhaoqiang Jiang, Junlin Jia, Yuan Fang, Li Shi, Chensheng Alex Lu & Jianlin Lou*. Novel DNA methylation biomarkers for hexavalent chromium exposure: an epigenome-wide analysis, Epigenomics. 2020 Feb;12(3):221-233. doi: 10.2217/epi-2019-0216.

8. Hangbiao Jin, Shu Lin, Wei Dai, Lingfang Feng, Tao Li, Jianlin Lou*, Quan Zhang. Exposure sources of perfluoroalkyl acids and influence of age and gender on concentrations of chlorinated polyfluorinated ether sulfonates in human serum from China, Environ Int. 2020 May; 138:105651. doi: 10.1016/j. envint. 2020. 105651.

9. Peiwei Xu, Lizhi Wu, Yuan Chen, Dandan Xu, Xiaofeng Wang, Qiuli Fu, Zhijian Chen*, Xiaoming Lou*, Jianlin Lou*. A cross-sectional study on school-age children living near a municipal waste incinerator: Urinary metal levels and renal impairment assessment, Chemosphere. 2020 Feb; 241:125081. doi: 10.1016/j.chemosphere.2019.125081.

10. JunlinJia#, TaoLi#, Chunji Yao, Junfei Chen, Lingfang Feng, Zhaoqiang Jiang, Li Shi, Jiaqi Liu, Junqiang Chen, Jianlin Lou*. Circulating differential miRNAs profiling and expression in hexavalent chromium exposed electroplating workers, Chemosphere. 2020 July, 260(6):127546. doi: 10.1016/j.chemosphere.2020.127546

11. Xu P, Wu L, Chen Y, Xu D, Wang X, Fu Q, Chen Z, Lou X, Lou J*. A cross-sectional study on school-age children living near a municipal waste incinerator: Urinary metal levels and renal impairment assessment. Chemosphere. 2019 Oct 8;241:125081.

12. Guo X, Feng L, Lemos B, Lou J*. DNA methylation modifications induced by hexavalent chromium. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2019;37(3):133-145. doi: 10.1080/10590501.2019.1592640. Epub 2019 May 13.

13. Xu P, Chen Z, Chen Y, Feng L, Wu L, Xu D, Wang X, Lou X, Lou J*. Body burdens of heavy metals associated with epigenetic damage in children living in the vicinity of a municipal waste incinerator. Chemosphere. 2019 May 3;229:160-168. doi: 10.1016/j.chemosphere.2019.05.016. [Epub ahead of print]

14. Jiang Z, Wang J, Guo X, Feng L, Yu M, Zhou J, Ye Y, Mei L, Ju L, Yu D, Shi L, Lu Alex C, Yu W, Lou J*. Menstrual disorders and occupational exposures among female nurses: A nationwide cross-sectional study. Int J Nurs Stud. 2019 Apr 19;95:49-55. doi: 10.1016/j.ijnurstu.2019.04.010. [Epub ahead of print]

15. Jiang Y, Luo Y, Tang Y, Moats R, Warburton D, Zhou S, Lou J, Pryhuber GS, Shi W, Wang LL. Alteration of cystic airway mesenchyme in congenital pulmonary airway malformation. Sci Rep. 2019 Mar 28;9(1):5296. doi: 10.1038/s41598-019-41777-y.

16. Yu D, Tong Y, Guo X, Feng L, Jiang Z, Ying S, Jia J, Fang Y, Yu M, Xia H, Shi L, Lou J*. Diagnostic Value of Concentration of Circulating Cell-Free DNA in Breast Cancer: A Meta-Analysis. Front Oncol. 2019 Mar 1;9:95. doi: 10.3389/fonc.2019.00095. eCollection 2019.

17. Jia J, Guo X, Feng L, Yin X, Zhu L, Li J, Yu D, Fang Y, Jiang Z, Yu M, Xia H, Shi L, Ju L, Zhang M, Xiao Y, Lu CA, Shi W, Zhang X, Lou J. Genome-wide profiling reveals novel microRNAs in hand-spinning-specific chrysotile exposure. Epigenomics. 2019 Jan 21. doi: 10.2217/epi-2018-0143. [Epub ahead of print]

18. Xia H, Ying S, Feng L, Wang H, Yao C, Li T, Zhang Y, Fu S, Ding D, Guo X, Tong Y, Wang X, Chen Z, Jiang Z, Zhang X, Lemos B, Lou J. Decreased 8-oxoguanine DNA glycosylase 1 (hOGG1) expression and DNA oxidation damage induced by Cr (VI). Chem Biol Interact. 2019 Feb 1;299:44-51. doi: 10.1016/j.cbi.2018.11.019. Epub 2018 Nov 27.

19. Zhang Q, Li Z, Chang CH, Lou JL, Zhao MR, Lu C. Potential human exposures to neonicotinoid insecticides: A review. Environ Pollut. 2018 May;236:71-81. doi: 10.1016/j.envpol.2017.12.101.

20. Jiang Z, Chen T, Chen J, Ying S, Gao Z, He X, Miao C, Yu M, Feng L, Xia H, Wu W, Chen R, Morinaga K, Lou J, Zhang X. Hand-spinning chrysotile exposure and risk of malignant mesothelioma: A case-control study in Southeastern China. Int J Cancer. 2018 Feb 1;142(3):514-523. doi: 10.1002/ijc.31077. Epub 2017 Oct 10.

21. Jiang Z, Ying S, Shen W, He X, Chen J, Xia H, Yu M, Xiao Y, Feng L, Zhu L, Ju L, Guo X, Zhang Y, Shen JW, Tong Y, Zhang X, Lou J. Plasma Fibulin-3 as a Potential Biomarker for Patients with Asbestos-Related Diseases in the Han Population. Dis Markers. 2017;2017:1725354. doi: 10.1155/2017/1725354. Epub 2017 Oct 22.

22. Wu W, Jiang H, Guo X, Wang Y, Ying S, Feng L, Li T, Xia H, Zhang Y, Chen R, Chen T, Lou J. The Protective Role of Hyaluronic Acid in Cr(VI)-Induced Oxidative Damage in Corneal Epithelial Cells. J Ophthalmol. 2017;2017:3678586. doi: 10.1155/2017/3678586. Epub 2017 Mar 27.

23. Ying S, Jiang Z, He X, Yu M, Chen R, Chen J, Ru G, Chen Y, Chen W, Zhu L, Li T, Zhang Y, Guo X, Yin X, Zhang X, Lou J. Serum HMGB1 as a Potential Biomarker for Patients with Asbestos-Related Diseases. Dis Markers. 2017;2017:5756102. doi: 10.1155/2017/5756102. Epub 2017 Mar 1.

发明专利

获国家发明专利4项

科研获奖

获省科技进步二等奖和厅局级一等奖各1项